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Yes, I know it's a security feature, but it's very frustrating for my colleagues that constantly download PDFs via Internet Explorer, confirming each and every file download individually.  This reg add command will disable that file download confirmation window.  Use this at your own risk as it is disabling a security feature.

REG ADD HKCU\Software\Microsoft\Windows\Shell\AttachmentExecute\{0002DF01-0000-0000-C000-000000000046} /v AcroPDF.PDF.1 /t REG_DWORD /d 00000000 /f